U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    blos-2 Biogenesis of lysosome-related organelles complex 1 subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 177395, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    blos-2
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1 subunit 2
    Primary source
    WormBase:WBGene00022251
    Locus tag
    CELE_Y73B6BL.30
    See related
    AllianceGenome:WB:WBGene00022251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gamma-tubulin binding activity. Involved in endosomal transport. Predicted to be part of BLOC-1 complex; BORC complex; and gamma-tubulin complex. Is expressed in head; pharyngeal-intestinal valve; and pharynx. Orthologous to human BLOC1S2 (biogenesis of lysosomal organelles complex 1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See blos-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (6334215..6335168)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm8 Neighboring gene Protein seu-1 Neighboring gene Macrophage migration inhibitory factor Neighboring gene PNPLA domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Niwa S, et al. Curr Biol, 2017 Sep 11. PMID 28823680, Free PMC Article
    2. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
    3. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of BORC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Biogenesis of lysosome-related organelles complex 1 subunit 2
    NP_001368404.1
    • Confirmed by transcript evidence
    NP_500967.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6334215..6335168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068566.6 → NP_500967.1  Biogenesis of lysosome-related organelles complex 1 subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XD3
      Conserved Domains (1) summary
      pfam10046
      Location:31 → 124
      BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2

    2. NM_001380271.1 → NP_001368404.1  Biogenesis of lysosome-related organelles complex 1 subunit 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLS1
      Conserved Domains (1) summary
      pfam10046
      Location:1 → 69
      BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XD3.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools