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    degt-1 Acid-sensing ion channel 1 [ Caenorhabditis elegans ]

    Gene ID: 184921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    degt-1
    Official Full Name
    Acid-sensing ion channel 1
    Primary source
    WormBase:WBGene00009109
    Locus tag
    CELE_F25D1.4
    See related
    AllianceGenome:WB:WBGene00009109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See degt-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (10540324..10545756)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Single-stranded DNA-binding protein Neighboring gene DeHydrogenases, Short chain Neighboring gene Serpentine receptor class delta-34 Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation linked to degt-1(ok3307) in C. elegans strain VC2633 affects rpm-1. Jin EJ, et al. MicroPubl Biol, 2022. PMID 35622515, Free PMC Article
    2. Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Chatzigeorgiou M, et al. Nat Neurosci, 2010 Jul. PMID 20512132, Free PMC Article
    3. Parallel Processing of Two Mechanosensory Modalities by a Single Neuron in C. elegans. Tao L, et al. Dev Cell, 2019 Dec 2. PMID 31735664, Free PMC Article
    4. DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs. Fechner S, et al. J Gen Physiol, 2021 Apr 5. PMID 33656557, Free PMC Article
    5. Dendrites use mechanosensitive channels to proofread ligand-mediated neurite extension during morphogenesis. Tao L, et al. Dev Cell, 2022 Jul 11. PMID 35709764

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acid-sensing ion channel 1
    NP_505703.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10540324..10545756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073302.4 → NP_505703.3  Acid-sensing ion channel 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505703.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19777
      Conserved Domains (2) summary
      pfam00858
      Location:44 → 318
      ASC; Amiloride-sensitive sodium channel
      cl02990
      Location:704 → 836
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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