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    swip-10 Metallo-beta-lactamase domain-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swip-10
    Official Full Name
    Metallo-beta-lactamase domain-containing protein 1
    Primary source
    WormBase:WBGene00018738
    Locus tag
    CELE_F53B1.6
    See related
    AllianceGenome:WB:WBGene00018738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in cytosol. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See swip-10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (2114618..2118262, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Conserved plasma membrane protein Neighboring gene Sphingomyelin synthase-related 1 Neighboring gene NAD(P)-binding domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-5 subunit Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease? Rodriguez P, et al. J Cell Physiol, 2024 Jun. PMID 37795580
    2. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. Hardaway JA, et al. J Neurosci, 2015 Jun 24. PMID 26109664, Free PMC Article
    3. Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1. Refai O, et al. Mol Pharmacol, 2022 Mar. PMID 34906999, Free PMC Article
    4. Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Gibson CL, et al. PLoS Genet, 2018 Mar. PMID 29590100, Free PMC Article
    5. Serotonin and dopamine modulate aging in response to food odor and availability. Miller HA, et al. Nat Commun, 2022 Jun 7. PMID 35672307, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Metallo-beta-lactamase domain-containing protein 1
    NP_001359973.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2114618..2118262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373238.1 → NP_001359973.1  Metallo-beta-lactamase domain-containing protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20700
      Conserved Domains (1) summary
      cd07711
      Location:281 → 475
      MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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