ccct-1 Coiled-coil and C2 domain-containing protein 1-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ccct-1
Official Full Name: Coiled-coil and C2 domain-containing protein 1-like
Primary source: WormBase:WBGene00012578
Locus tag: CELE_Y37H9A.3
See related: AllianceGenome:WB:WBGene00012578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 3 and intellectual disability. Orthologous to several human genes including CC2D1B (coiled-coil and C2 domain containing 1B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ccct-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (13778895..13792249)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37H9A.3 (e-PCR)
- UniSTS:319751

Y37H9A.2 (e-PCR)
- UniSTS:312985

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Coiled-coil and C2 domain-containing protein 1-like

NP_001359623.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13778895..13792249

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373656.2 → NP_001359623.1 Coiled-coil and C2 domain-containing protein 1-like [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M8

Conserved Domains (2) summary

smart00685
Location:454 → 512

DM14; Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241

cd08690
Location:621 → 779

C2_Freud-1; C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1)