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    mys-2 histone acetyltransferase [ Caenorhabditis elegans ]

    Gene ID: 173281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mys-2
    Official Full Name
    histone acetyltransferase
    Primary source
    WormBase:WBGene00010537
    Locus tag
    CELE_K03D10.3
    See related
    AllianceGenome:WB:WBGene00010537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of MSL complex; NSL complex; and NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in germ line. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mys-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (14118751..14127202)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Neighboring gene TLC domain-containing protein fld-1 Neighboring gene WAP-type 'four-disulfide core Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of a MOF histone acetyltransferase-containing NSL complex in C. elegans. Hoe M, et al. Worm, 2014 Oct-Dec. PMID 26430553, Free PMC Article
    2. Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans. Shibata Y, et al. Biol Open, 2019 Jan 17. PMID 30635266, Free PMC Article
    3. SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans. Yücel D, et al. Dev Biol, 2014 Aug 15. PMID 24882710
    4. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Shibata Y, et al. Development, 2010 Apr. PMID 20181741
    5. HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans. Shibata Y, et al. Development, 2014 Jan. PMID 24346701

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H4K16 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase
    NP_001309531.1
    • Confirmed by transcript evidence
    NP_001309533.1
    • Confirmed by transcript evidence
    NP_001317768.1
    • Confirmed by transcript evidence
    NP_001317769.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14118751..14127202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330941.4 → NP_001317768.1  histone acetyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MAQ8

    2. NM_001322689.3 → NP_001309531.1  histone acetyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MAV3
      Conserved Domains (3) summary
      pfam01853
      Location:244 → 418
      MOZ_SAS; MOZ/SAS family
      pfam11717
      Location:53 → 110
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:170 → 418
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. NM_001330942.3 → NP_001317769.1  histone acetyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MC76

    4. NM_001322692.3 → NP_001309533.1  histone acetyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBB1
      Conserved Domains (1) summary
      cl17182
      Location:2 → 83
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version

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