atg-9 Autophagy-related protein 9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atg-9
Official Full Name: Autophagy-related protein 9
Primary source: WormBase:WBGene00020706
Locus tag: CELE_T22H9.2
See related: AllianceGenome:WB:WBGene00020706
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in regulation of presynapse assembly. Located in cytoplasm and presynapse. Is expressed in several structures, including AIY; hypodermis; nerve ring; neuronal sheath cell; and spermatheca. Orthologous to several human genes including ATG9A (autophagy related 9A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atg-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (349385..359658)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9.
Title: The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9.
The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
Title: The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
RAB-10 GTPase cycling was required to control the size of GFP::ATG-9 foci. Collectively, these data support a model where rab-10 controls autophagic flux by regulating autophagosome formation and maturation.
Title: The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9.
findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment
Title: KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22H9.2 (e-PCR)
- UniSTS:319672

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Autophagy-related protein 9

NP_001364810.1

Confirmed by transcript evidence

NP_503178.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

349385..359658

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070777.5 → NP_503178.2 Autophagy-related protein 9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q3T903, Q9TXN6

Conserved Domains (1) summary

pfam04109
Location:236 → 589

APG9; Autophagy protein Apg9
NM_001377584.1 → NP_001364810.1 Autophagy-related protein 9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0M4