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    soc-1 Multisubstrate adapter protein soc-1 [ Caenorhabditis elegans ]

    Gene ID: 178855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    soc-1
    Official Full Name
    Multisubstrate adapter protein soc-1
    Primary source
    WormBase:WBGene00004928
    Locus tag
    CELE_F41F3.2
    See related
    AllianceGenome:WB:WBGene00004928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in dauer larval development. Is expressed in head; tail; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to several human genes including GAB1 (GRB2 associated binding protein 1); GAB2 (GRB2 associated binding protein 2); and GAB3 (GRB2 associated binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See soc-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4642952..4646931)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Phosphoethanolamine N-methyltransferase 2 Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Schutzman JL, et al. Mol Cell Biol, 2001 Dec. PMID 11689700, Free PMC Article
    2. The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Hopper NA. Genetics, 2006 May. PMID 16547100, Free PMC Article
    3. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Selfors LM, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618511, Free PMC Article
    4. An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. DeVore DL, et al. Cell, 1995 Nov 17. PMID 7585964
    5. Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Patel DS, et al. Genetics, 2008 Feb. PMID 18245374, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Multisubstrate adapter protein soc-1
    NP_504250.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4642952..4646931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071849.7 → NP_504250.2  Multisubstrate adapter protein soc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504250.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDJ4
      Conserved Domains (2) summary
      smart00233
      Location:8 → 133
      PH; Pleckstrin homology domain
      pfam00169
      Location:8 → 133
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDJ4.1

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