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    trak-1 HAP1 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trak-1
    Official Full Name
    HAP1 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00020838
    Locus tag
    CELE_T27A3.1
    See related
    AllianceGenome:WB:WBGene00020838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable myosin binding activity. Predicted to be involved in mitochondrion distribution; protein targeting; and vesicle transport along microtubule. Predicted to be located in axon cytoplasm. Predicted to be active in cytoplasmic vesicle and mitochondrion. Is expressed in several structures, including CAN; ganglia; hermaphrodite somatic gonadal cell; pharyngeal muscle cell; and rectum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to several human genes including TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trak-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (6123120..6126875)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phorbol-ester/DAG-type domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA Neighboring gene Peptide transporter 3 Neighboring gene ncRNA Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans. Norflus F, et al. J Neurosci Res, 2016 Sep. PMID 27319755, Free PMC Article
    2. A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types. Mercer KB, et al. J Mol Neurosci, 2009 Jan. PMID 18592415, Free PMC Article
    3. Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. Lumsden AL, et al. BMC Evol Biol, 2016 Oct 13. PMID 27737633, Free PMC Article
    4. CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon. Chen YC, et al. PLoS Genet, 2021 Feb. PMID 33571181, Free PMC Article
    5. Metaxins are core components of mitochondrial transport adaptor complexes. Zhao Y, et al. Nat Commun, 2021 Jan 4. PMID 33397950, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T27A3.1 is expressed in many cell types including a subset of chemosensory neurons in the head and tail
      Title: A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HAP1 N-terminal domain-containing protein
    NP_001364787.1
    • Confirmed by transcript evidence
    NP_491766.2
    • Confirmed by transcript evidence
    NP_871887.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6123120..6126875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059365.7 → NP_491766.2  HAP1 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491766.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NB7
      Conserved Domains (1) summary
      pfam04849
      Location:30 → 244
      HAP1_N; HAP1 N-terminal conserved region

    2. NM_001377582.2 → NP_001364787.1  HAP1 N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91503
      Conserved Domains (1) summary
      pfam04849
      Location:30 → 244
      HAP1_N; HAP1 N-terminal conserved region

    3. NM_182087.6 → NP_871887.1  HAP1 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NB6
      Conserved Domains (1) summary
      pfam04849
      Location:30 → 244
      HAP1_N; HAP1 N-terminal conserved region
    Nucleotide Protein
    Heading Accession and Version

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