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    tyr-4 ShKT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyr-4
    Official Full Name
    ShKT domain-containing protein
    Primary source
    WormBase:WBGene00016419
    Locus tag
    CELE_C34G6.2
    See related
    AllianceGenome:WB:WBGene00016419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human DCT (dopachrome tautomerase); TYR (tyrosinase); and TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyr-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (5898303..5902115)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene P-GlycoProtein related Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene Signal transducing adapter molecule 1 Neighboring gene HEAT repeat protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
    2. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ShKT domain-containing protein
    NP_491709.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5898303..5902115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059308.9 → NP_491709.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01497
      Conserved Domains (3) summary
      smart00254
      Location:502 → 536
      ShKT; ShK toxin domain
      pfam00264
      Location:137 → 319
      Tyrosinase; Common central domain of tyrosinase
      pfam01549
      Location:611 → 645
      ShK; ShK domain-like
    Nucleotide Protein
    Heading Accession and Version

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