gck-3 Germinal center kinase 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gck-3
Official Full Name: Germinal center kinase 3
Primary source: WormBase:WBGene00013355
Locus tag: CELE_Y59A8B.23
See related: AllianceGenome:WB:WBGene00013355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in epithelial tube morphogenesis; hyperosmotic response; and multicellular organismal-level water homeostasis. Acts upstream of with a positive effect on positive regulation of gene expression. Located in cytoplasm. Is expressed in body wall musculature; excretory system; hypodermis; oocyte; and spermatheca. Orthologous to human OXSR1 (oxidative stress responsive kinase 1) and STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gck-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (17953886..17966847, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report role of multisite phosphorylation in regulating GCK-3 activity.
Title: Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation.
We postulate that MEK-2/MPK-1 functions upstream from GCK-3 to regulate its activity during cell volume and meiotic cell cycle changes.
Title: C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling.
The Caenorhabditis elegans gck-3 is essential for postembryonic developmental timing and regulates chromosome segregation.
Title: The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation.
These results indicate that WNK-1 controls the tubular formation of excretory canals by activating GCK-3, resulting in downregulation of CIC channel activity.
Title: Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
WNK-1 functions upstream of GCK-3 in a manner similar to that postulated for its mammalian homologs
Title: Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y59A8A.c (e-PCR)
- UniSTS:323164

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level water homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Germinal center kinase 3

NP_001129918.1

Confirmed by transcript evidence

NP_001379534.1

Confirmed by transcript evidence

NP_507517.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

17953886..17966847 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075116.7 → NP_507517.2 Germinal center kinase 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507517.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5QSI7, F9UKV1, G5EEN4

Conserved Domains (2) summary

smart00220
Location:108 → 386

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:106 → 386

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
NM_001136446.4 → NP_001129918.1 Germinal center kinase 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129918.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEN4

Conserved Domains (2) summary

smart00220
Location:1 → 229

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 229

PKc_like; Protein Kinases, catalytic domain
NM_001392687.1 → NP_001379534.1 Germinal center kinase 3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd06610
Location:106 → 386

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase