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    dsl-1 Delta-like protein dsl-1 [ Caenorhabditis elegans ]

    Gene ID: 176939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsl-1
    Official Full Name
    Delta-like protein dsl-1
    Primary source
    WormBase:WBGene00001103
    Locus tag
    CELE_W09G12.4
    See related
    AllianceGenome:WB:WBGene00001103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including P6.p hermaphrodite; P6.pa; P6.paa; P6.pap; and vulval cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dsl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (1207218..1208080, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Delta-like protein Neighboring gene pseudo Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network. Hoyos E, et al. Curr Biol, 2011 Apr 12. PMID 21458263, Free PMC Article
    2. Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling. Foehr ML, et al. Dev Biol, 2008 Jan 1. PMID 18036582, Free PMC Article
    3. Vulval development: the battle between Ras and Notch. Sundaram MV. Curr Biol, 2004 Apr 20. PMID 15084301
    4. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. Komatsu H, et al. PLoS Biol, 2008 Aug 12. PMID 18700817, Free PMC Article
    5. A "latent niche" mechanism for tumor initiation. McGovern M, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564624, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Delta-like protein dsl-1
    NP_500054.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1207218..1208080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067653.4 → NP_500054.1  Delta-like protein dsl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45201
      Conserved Domains (2) summary
      cd00054
      Location:175 → 210
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl19567
      Location:112 → 164
      DSL; Delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45201.1

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