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    lys-10 LYSozyme [ Caenorhabditis elegans ]

    Gene ID: 184622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-10
    Official Full Name
    LYSozyme
    Primary source
    WormBase:WBGene00003099
    Locus tag
    CELE_F17E9.11
    See related
    AllianceGenome:WB:WBGene00003099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in innate immune response and signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_003282.8 (8332826..8333518)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histone H2B 1 Neighboring gene Histone H2A Neighboring gene Histone H4 Neighboring gene Histone H3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. Kruempel JCP, et al. Geroscience, 2020 Dec. PMID 32399915, Free PMC Article
    2. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article
    3. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Samuelson AV, et al. Cold Spring Harb Symp Quant Biol, 2007. PMID 18419309
    4. Inducible antibacterial defense system in C. elegans. Mallo GV, et al. Curr Biol, 2002 Jul 23. PMID 12176330
    5. Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model. Harr JC, et al. Genes Dev, 2020 Apr 1. PMID 32139421, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LYSozyme
    NP_501405.1
    • Product from WormBase gene class lys;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8332826..8333518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069004.3 → NP_501405.1  LYSozyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61518
      Conserved Domains (1) summary
      cd06416
      Location:18 → 228
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version

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