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    fln-1 Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog [ Caenorhabditis elegans ]

    Gene ID: 176855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fln-1
    Official Full Name
    Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog
    Primary source
    WormBase:WBGene00022048
    Locus tag
    CELE_Y66H1B.2
    See related
    AllianceGenome:WB:WBGene00022048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including axon development; semaphorin-plexin signaling pathway; and uterus morphogenesis. Located in actin filament. Is expressed in several structures, including body wall musculature; gonad; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Larsen syndrome; X-linked chronic idiopathic intestinal pseudo-obstruction; bone development disease (multiple); heart valve disease (multiple); and myopathy (multiple). Orthologous to several human genes including FLNB (filamin B) and FLNC (filamin C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fln-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    25
    Sequence:
    Chromosome: IV; NC_003282.8 (359223..376015, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Peroxisomal membrane protein 4 Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sphingosine-1-phosphate lyase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. Kelley CA, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 32969593, Free PMC Article
    2. FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. Kovacevic I, et al. Dev Biol, 2010 Nov 15. PMID 20707996, Free PMC Article
    3. Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. DeMaso CR, et al. PLoS One, 2011. PMID 21799850, Free PMC Article
    4. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. Kovacevic I, et al. PLoS Genet, 2013 May. PMID 23671426, Free PMC Article
    5. Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction. Avivi Kela S, et al. J Cell Biol, 2023 Feb 6. PMID 36574264, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2
      Title: Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.
    2. UNC-33, CRMP1 C. elegans homologue, interacts with FLN-1
      Title: Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
    3. this study answers long-standing questions concerning calcium signaling dynamics in the C. elegans spermatheca and suggests FLN-1 is needed in response to oocyte entry to trigger calcium release and coordinated contraction of the spermathecal tissue.
      Title: Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in uterus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog
    NP_001023550.2
    • Confirmed by transcript evidence
    NP_001023551.2
    • Confirmed by transcript evidence
    NP_001255220.1
    • Confirmed by transcript evidence
    NP_001255221.1
    • Confirmed by transcript evidence
    NP_001294360.1
    • Confirmed by transcript evidence
    NP_001294361.1
    • Confirmed by transcript evidence
    NP_001294362.1
    • Confirmed by transcript evidence
    NP_001294363.1
    • Confirmed by transcript evidence
    NP_001294364.1
    • Confirmed by transcript evidence
    NP_001294365.1
    • Confirmed by transcript evidence
    NP_001294366.1
    • Confirmed by transcript evidence
    NP_001294367.1
    • Confirmed by transcript evidence
    NP_001294368.1
    • Confirmed by transcript evidence
    NP_001294369.1
    • Confirmed by transcript evidence
    NP_001294370.1
    • Confirmed by transcript evidence
    NP_001294371.1
    • Confirmed by transcript evidence
    NP_001294372.1
    • Confirmed by transcript evidence
    NP_001367770.1
    • Product from WormBase gene class fln;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      359223..376015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268291.4 → NP_001255220.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IMZ7
      Conserved Domains (5) summary
      TIGR00036
      Location:1091 → 1207
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1429 → 1512
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 275
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1735 → 1786
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:641 → 735
      Filamin; Filamin/ABP280 repeat

    2. NM_001307431.4 → NP_001294360.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM01
      Conserved Domains (5) summary
      TIGR00036
      Location:1091 → 1207
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1482 → 1565
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 275
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1788 → 1839
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:641 → 735
      Filamin; Filamin/ABP280 repeat

    3. NM_001307435.3 → NP_001294364.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBJ9
      Conserved Domains (5) summary
      TIGR00036
      Location:1093 → 1209
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1484 → 1567
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 277
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1790 → 1841
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:643 → 737
      Filamin; Filamin/ABP280 repeat

    4. NM_001307432.3 → NP_001294361.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PR92
      Conserved Domains (5) summary
      TIGR00036
      Location:1093 → 1209
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1482 → 1565
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 277
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1788 → 1839
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:643 → 737
      Filamin; Filamin/ABP280 repeat

    5. NM_001028379.5 → NP_001023550.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023550.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IMZ5
      Conserved Domains (4) summary
      smart00557
      Location:1480 → 1563
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:27 → 131
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00307
      Location:152 → 248
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1480 → 1560
      Filamin; Filamin/ABP280 repeat

    6. NM_001268292.3 → NP_001255221.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IMZ8
      Conserved Domains (5) summary
      TIGR00036
      Location:1091 → 1207
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1431 → 1514
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 275
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1737 → 1788
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:641 → 735
      Filamin; Filamin/ABP280 repeat

    7. NM_001307433.3 → NP_001294362.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEE3
      Conserved Domains (5) summary
      TIGR00036
      Location:1093 → 1209
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1431 → 1514
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 277
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1737 → 1788
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:643 → 737
      Filamin; Filamin/ABP280 repeat

    8. NM_001307434.3 → NP_001294363.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB53
      Conserved Domains (5) summary
      TIGR00036
      Location:1093 → 1209
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1433 → 1516
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:23 → 277
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:1739 → 1790
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:643 → 737
      Filamin; Filamin/ABP280 repeat

    9. NM_001307437.3 → NP_001294366.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PR97
      Conserved Domains (5) summary
      TIGR00036
      Location:957 → 1073
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1295 → 1378
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 114
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1601 → 1652
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:1217 → 1287
      Filamin; Filamin/ABP280 repeat

    10. NM_001307438.3 → NP_001294367.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEE8
      Conserved Domains (5) summary
      TIGR00036
      Location:957 → 1073
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1297 → 1380
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 114
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1603 → 1654
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:507 → 601
      Filamin; Filamin/ABP280 repeat

    11. NM_001307436.3 → NP_001294365.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM04
      Conserved Domains (5) summary
      TIGR00036
      Location:957 → 1073
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1346 → 1429
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 114
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1652 → 1703
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:507 → 601
      Filamin; Filamin/ABP280 repeat

    12. NM_001307439.3 → NP_001294368.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294368.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB58
      Conserved Domains (5) summary
      TIGR00036
      Location:957 → 1073
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1348 → 1431
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 114
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1654 → 1705
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:507 → 601
      Filamin; Filamin/ABP280 repeat

    13. NM_001307441.3 → NP_001294370.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM09
      Conserved Domains (5) summary
      TIGR00036
      Location:959 → 1075
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1297 → 1380
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 116
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1603 → 1654
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:1219 → 1289
      Filamin; Filamin/ABP280 repeat

    14. NM_001307442.3 → NP_001294371.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRA0
      Conserved Domains (5) summary
      TIGR00036
      Location:959 → 1075
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1299 → 1382
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 116
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1605 → 1656
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:509 → 603
      Filamin; Filamin/ABP280 repeat

    15. NM_001307440.3 → NP_001294369.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBK4
      Conserved Domains (5) summary
      TIGR00036
      Location:959 → 1075
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1348 → 1431
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 116
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1654 → 1705
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:509 → 603
      Filamin; Filamin/ABP280 repeat

    16. NM_001307443.3 → NP_001294372.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEF1
      Conserved Domains (5) summary
      TIGR00036
      Location:959 → 1075
      dapB; 4-hydroxy-tetrahydrodipicolinate reductase
      smart00557
      Location:1350 → 1433
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00307
      Location:17 → 116
      CH; Calponin homology (CH) domain
      pfam00630
      Location:1656 → 1707
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:509 → 603
      Filamin; Filamin/ABP280 repeat

    17. NM_001380004.1 → NP_001367770.1  FiLamiN (actin binding protein) homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IMZ6
      Conserved Domains (3) summary
      smart00557
      Location:61 → 144
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:366 → 419
      Filamin; Filamin/ABP280 repeat
      cl27659
      Location:3 → 53
      Filamin; Filamin/ABP280 repeat

    18. NM_001028380.5 → NP_001023551.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023551.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYW4
      Conserved Domains (4) summary
      smart00557
      Location:959 → 1049
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:27 → 131
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00307
      Location:152 → 248
      CH; Calponin homology (CH) domain
      pfam00630
      Location:956 → 1042
      Filamin; Filamin/ABP280 repeat
    Nucleotide Protein
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