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    rgs-6 Regulator of G-protein signaling rgs-6 [ Caenorhabditis elegans ]

    Gene ID: 180840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs-6
    Official Full Name
    Regulator of G-protein signaling rgs-6
    Primary source
    WormBase:WBGene00004349
    Locus tag
    CELE_C41G11.3
    See related
    AllianceGenome:WB:WBGene00004349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgs-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (5720440..5729023, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Cytochrome P450 Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Dong MQ, et al. Genes Dev, 2000 Aug 15. PMID 10950865, Free PMC Article
    2. Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. Hoogewijs D, et al. BMC Mol Biol, 2008 Jan 22. PMID 18211699, Free PMC Article
    3. Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase. Zapata RC, et al. Nat Commun, 2022 Aug 30. PMID 36042358, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Regulator of G-protein signaling rgs-6
    NP_001294820.1
    • Confirmed by transcript evidence
    NP_001294821.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5720440..5729023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307892.4 → NP_001294821.1  Regulator of G-protein signaling rgs-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BQK8
      Conserved Domains (1) summary
      smart00315
      Location:47 → 157
      RGS; Regulator of G protein signalling domain

    2. NM_001307891.4 → NP_001294820.1  Regulator of G-protein signaling rgs-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A078BPH3, A0A078BQK8, Q18562, Q18563
      Conserved Domains (1) summary
      smart00315
      Location:47 → 157
      RGS; Regulator of G protein signalling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18563.4

    Gene LinkOut

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