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    chs-2 Chitin synthase chs-2;chitin synthase [ Caenorhabditis elegans ]

    Gene ID: 173405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chs-2
    Official Full Name
    Chitin synthase chs-2;chitin synthase
    Primary source
    WormBase:WBGene00000497
    Locus tag
    CELE_F48A11.1
    See related
    AllianceGenome:WB:WBGene00000497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chitin synthase activity. Involved in chitin biosynthetic process and positive regulation of nematode larval development. Predicted to be located in plasma membrane. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chs-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    20
    Sequence:
    Chromosome: II; NC_003280.10 (196985..211941)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene Serpentine receptor class gamma Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box associated domain-containing protein;FBA_2 domain-containing protein Neighboring gene UBX domain-containing protein 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively. Zhang Y, et al. Dev Biol, 2005 Sep 15. PMID 16098962
    2. Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia. Veronico P, et al. Mol Genet Genomics, 2001 Sep. PMID 11589574
    3. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    4. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
    5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The chitin synthase gene chs-2 is essential for C. elegans development and responsible for chitin deposition in the pharynx.
      Title: The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chitin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chitin synthase chs-2;chitin synthase
    NP_001300544.1
    • Confirmed by transcript evidence
    NP_001300545.1
    • Partially confirmed by transcript evidence
    NP_493682.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      196985..211941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313616.3 → NP_001300545.1  chitin synthase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR16
      Conserved Domains (2) summary
      cd04190
      Location:731 → 1050
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
      pfam03142
      Location:881 → 1225
      Chitin_synth_2; Chitin synthase

    2. NM_001313615.3 → NP_001300544.1  Chitin synthase chs-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd04190
      Location:637 → 956
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
      pfam03142
      Location:787 → 1131
      Chitin_synth_2; Chitin synthase

    3. NM_061281.6 → NP_493682.2  Chitin synthase chs-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493682.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3ATY7, G5EBQ8
      Conserved Domains (2) summary
      cd04190
      Location:699 → 1018
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
      cl26109
      Location:849 → 1193
      Chitin_synth_2; Chitin synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBQ8.1

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