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    frm-8 FERM and PDZ domain-containing protein 4 [ Caenorhabditis elegans ]

    Gene ID: 175428, updated on 9-Dec-2024

    Summary

    Official Symbol
    frm-8
    Official Full Name
    FERM and PDZ domain-containing protein 4
    Primary source
    WormBase:WBGene00001494
    Locus tag
    CELE_H09G03.2
    See related
    AllianceGenome:WB:WBGene00001494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in nervous system. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to human FRMPD1 (FERM and PDZ domain containing 1); FRMPD3 (FERM and PDZ domain containing 3); and FRMPD4 (FERM and PDZ domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See frm-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (3200795..3219150, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Putative protein heh-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    FERM and PDZ domain-containing protein 4
    NP_497672.2
    • Confirmed by transcript evidence
    NP_741109.1
    • Confirmed by transcript evidence
    NP_741110.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3200795..3219150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171097.5NP_741110.1  FERM and PDZ domain-containing protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741110.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXE9
      Conserved Domains (5) summary
      smart00295
      Location:209452
      B41; Band 4.1 homologues
      cd00201
      Location:5685
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:94169
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:303452
      FERM_M; FERM central domain
      pfam09379
      Location:212254
      FERM_N; FERM N-terminal domain
    2. NM_171096.7NP_741109.1  FERM and PDZ domain-containing protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXF0
      Conserved Domains (6) summary
      smart00295
      Location:248491
      B41; Band 4.1 homologues
      cd00201
      Location:95124
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:133208
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:342491
      FERM_M; FERM central domain
      pfam00397
      Location:6584
      WW; WW domain
      pfam09379
      Location:251293
      FERM_N; FERM N-terminal domain
    3. NM_065271.7NP_497672.2  FERM and PDZ domain-containing protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497672.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8ITW4
      Conserved Domains (5) summary
      smart00295
      Location:209452
      B41; Band 4.1 homologues
      cd00201
      Location:5685
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:94169
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:303452
      FERM_M; FERM central domain
      pfam09379
      Location:212254
      FERM_N; FERM N-terminal domain