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    efl-2 Transcription factor efl-2 [ Caenorhabditis elegans ]

    Gene ID: 174980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    efl-2
    Official Full Name
    Transcription factor efl-2
    Primary source
    WormBase:WBGene00001162
    Locus tag
    CELE_Y48C3A.17
    See related
    AllianceGenome:WB:WBGene00001162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in dorsal nerve cord; head muscle; intestine; spermatheca; and ventral nerve cord. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See efl-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (13406140..13411895)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene Threonylcarbamoyl-AMP synthase Neighboring gene Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. Polli JR, et al. Arch Toxicol, 2014 Mar. PMID 24496467
    2. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. O'Donnell B, et al. Toxicol Sci, 2017 Apr 1. PMID 28003440, Free PMC Article
    3. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Schertel C, et al. Development, 2007 Oct. PMID 17881492
    4. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Polli JR, et al. Methods Mol Biol, 2021. PMID 34097257
    5. C. elegans class B synthetic multivulva genes act in G(1) regulation. Boxem M, et al. Curr Biol, 2002 Jun 4. PMID 12062054

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor efl-2
    NP_001122658.1
    • Confirmed by transcript evidence
    NP_001122660.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13406140..13411895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129188.4 → NP_001122660.1  Transcription factor efl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5HWA6, A5HWA8, Q9BIE8
      Conserved Domains (3) summary
      cd14660
      Location:105 → 140
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:40 → 99
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:110 → 200
      E2F_DD; Dimerization domain of E2F transcription factors

    2. NM_001129186.3 → NP_001122658.1  Transcription factor efl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HWA6
      Conserved Domains (3) summary
      cd14660
      Location:105 → 140
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:37 → 99
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:110 → 200
      E2F_DD; Dimerization domain of E2F transcription factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5HWA8.1

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