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    nprl-3 GATOR complex protein NPRL3 [ Caenorhabditis elegans ]

    Gene ID: 185331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nprl-3
    Official Full Name
    GATOR complex protein NPRL3
    Primary source
    WormBase:WBGene00018072
    Locus tag
    CELE_F35H10.7
    See related
    AllianceGenome:WB:WBGene00018072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in several processes, including TORC1 signaling; cellular response to amino acid starvation; and negative regulation of TORC1 signaling. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nprl-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (8297492..8299843)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SLC41A/MgtE integral membrane domain-containing protein Neighboring gene Tubulin-specific chaperone E Neighboring gene Spindle and kinetochore-associated protein 2 Neighboring gene Centromere protein X

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Zhu H, et al. Genes Dev, 2015 Jun 15. PMID 26109047, Free PMC Article
    2. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Zhu H, et al. Elife, 2013 May 21. PMID 23705068, Free PMC Article
    3. Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction. Ryan KC, et al. Antioxidants (Basel), 2022 Aug 24. PMID 36139715, Free PMC Article
    4. Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism. Diot C, et al. Nat Commun, 2022 Sep 23. PMID 36151093, Free PMC Article
    5. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Zhu M, et al. Dev Cell, 2021 Oct 11. PMID 34610328

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GATOR1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GATOR complex protein NPRL3
    NP_001294069.1
    • Confirmed by transcript evidence
    NP_501396.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8297492..8299843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068995.7 → NP_501396.1  GATOR complex protein NPRL3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20069
      Conserved Domains (1) summary
      cl24021
      Location:253 → 402
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    2. NM_001307140.3 → NP_001294069.1  GATOR complex protein NPRL3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LXA9
      Conserved Domains (1) summary
      cl24021
      Location:234 → 385
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20069.1

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