lcmt-1 Leucine carboxyl methyltransferase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lcmt-1
Official Full Name: Leucine carboxyl methyltransferase 1
Primary source: WormBase:WBGene00007137
Locus tag: CELE_B0285.4
See related: AllianceGenome:WB:WBGene00007137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein C-terminal leucine carboxyl O-methyltransferase activity. Predicted to be involved in regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be active in cytosol. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lcmt-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (4343446..4345222)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0285.4 (e-PCR)
- UniSTS:306713

B0285.3 (e-PCR)
- UniSTS:317809

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal leucine carboxyl O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Leucine carboxyl methyltransferase 1

NP_497875.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4343446..4345222

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065474.5 → NP_497875.1 Leucine carboxyl methyltransferase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497875.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46554

Conserved Domains (1) summary

pfam04072
Location:30 → 226

LCM; Leucine carboxyl methyltransferase