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    • Showing Current items.

    ccf-1 CCR4-NOT transcription complex subunit 7 [ Caenorhabditis elegans ]

    Gene ID: 176625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccf-1
    Official Full Name
    CCR4-NOT transcription complex subunit 7
    Primary source
    WormBase:WBGene00000369
    Locus tag
    CELE_Y56A3A.20
    See related
    AllianceGenome:WB:WBGene00000369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening and oogenesis. Located in P granule and P-body. Part of CCR4-NOT complex. Is expressed in germ line. Orthologous to several human genes including CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ccf-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (11918828..11920237, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Acyl carrier protein Neighboring gene Nuclear pore complex protein npp-16 Neighboring gene Zinc finger protein 593 homolog Neighboring gene Translocon-associated protein subunit delta Neighboring gene DUF1279 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans. Tabarraei H, et al. Aging Cell, 2023 Apr. PMID 36797658, Free PMC Article
    2. PUF proteins bind Pop2p to regulate messenger RNAs. Goldstrohm AC, et al. Nat Struct Mol Biol, 2006 Jun. PMID 16715093
    3. C. elegans homologue of the Caf1 gene, which encodes a subunit of the CCR4-NOT complex, is essential for embryonic and larval development and for meiotic progression. Molin L, et al. Gene, 2005 Sep 26. PMID 16039072
    4. FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Suh N, et al. Genetics, 2009 Apr. PMID 19221201, Free PMC Article
    5. The in vivo functional significance of PUF hub partnerships in C. elegans germline stem cells. Ferdous AS, et al. Development, 2023 May 1. PMID 37070766, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans.
      Title: CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans.
    2. FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction in control of GLD1 expression.
      Title: FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 7
    NP_499553.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11918828..11920237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067152.7 → NP_499553.1  CCR4-NOT transcription complex subunit 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17345
      Conserved Domains (1) summary
      cl23804
      Location:23 → 292
      CAF1; CAF1 family ribonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17345.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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