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    sqv-7 UDP-sugar transporter sqv-7 [ Caenorhabditis elegans ]

    Gene ID: 174145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqv-7
    Official Full Name
    UDP-sugar transporter sqv-7
    Primary source
    WormBase:WBGene00005025
    Locus tag
    CELE_C52E12.3
    See related
    AllianceGenome:WB:WBGene00005025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables UDP-N-acetylgalactosamine transmembrane transporter activity; UDP-galactose transmembrane transporter activity; and UDP-glucuronic acid transmembrane transporter activity. Involved in several processes, including egg-laying behavior; proteoglycan biosynthetic process; and pyrimidine nucleotide-sugar transmembrane transport. Located in cytoplasm. Is expressed in several structures, including hermaphrodite distal tip cell; intestine; nervous system; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to several human genes including SLC35D1 (solute carrier family 35 member D1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqv-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (7010811..7012690, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein unc-104 Neighboring gene tRNA-Ala Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene Lateral Signaling Target Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose. Berninsone P, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11259660, Free PMC Article
    2. An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Pedersen ME, et al. Science, 2013 Sep 20. PMID 24052309
    3. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Bulik DA, et al. Proc Natl Acad Sci U S A, 2000 Sep 26. PMID 11005858, Free PMC Article
    4. Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism. Caffaro CE, et al. J Biol Chem, 2007 Sep 21. PMID 17652078
    5. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391314, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylgalactosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylgalactosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-glucuronic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-sugar transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of distal tip cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-sugar transporter sqv-7
    NP_495436.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7010811..7012690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063035.6 → NP_495436.1  UDP-sugar transporter sqv-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18779
      Conserved Domains (1) summary
      pfam03151
      Location:21 → 299
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18779.1

    Gene LinkOut

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