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    ptr-18 Patched-related protein 18 [ Caenorhabditis elegans ]

    Gene ID: 174940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptr-18
    Official Full Name
    Patched-related protein 18
    Primary source
    WormBase:WBGene00004232
    Locus tag
    CELE_Y38F1A.3
    See related
    AllianceGenome:WB:WBGene00004232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in endocytosis and molting cycle. Acts upstream of or within nematode male tail mating organ morphogenesis. Located in apical plasma membrane. Is expressed in hypodermal cell and ventral cord blast cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptr-18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (12965546..12978171)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Exocyst complex component Sec10 Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase RNF170 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene G1/S-specific cyclin-D Neighboring gene Hydroxyacid-oxoacid transhydrogenase, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis. Chiyoda H, et al. PLoS Genet, 2021 Apr. PMID 33872306, Free PMC Article
    2. Muscle-epidermis interactions affect exoskeleton patterning in Caenorhabditis elegans. Broday L, et al. Dev Dyn, 2007 Nov. PMID 17937397
    3. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Kuwabara PE, et al. Genes Dev, 2000 Aug 1. PMID 10921907, Free PMC Article
    4. A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans. Guédon R, et al. Ecotoxicol Environ Saf, 2021 Dec 1. PMID 34544019
    5. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
      Title: Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Patched-related protein 18
    NP_496761.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12965546..12978171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064360.5 → NP_496761.3  Patched-related protein 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496761.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XWL9
      Conserved Domains (1) summary
      cl25655
      Location:72 → 834
      Patched; Patched family
    Nucleotide Protein
    Heading Accession and Version

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