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    dom-3 Decapping nuclease dom-3 [ Caenorhabditis elegans ]

    Gene ID: 172124, updated on 9-Dec-2024

    Summary

    Official Symbol
    dom-3
    Official Full Name
    Decapping nuclease dom-3
    Primary source
    WormBase:WBGene00001050
    Locus tag
    CELE_F54C1.2
    See related
    AllianceGenome:WB:WBGene00001050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 5'-diphosphatase activity. Predicted to be involved in NAD-cap decapping and nuclear-transcribed mRNA catabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See dom-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (5003450..5004933)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 30 homolog Neighboring gene Polycomb protein mes-3 Neighboring gene Uncharacterized protein Neighboring gene Sperm Specific Transcript Neighboring gene glucuronosyltransferase

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA NAD+-cap (NAD+-forming) hydrolase activity  
    enables RNA binding  
    enables mRNA 5'-diphosphatase activity  
    enables metal ion binding  
    enables nuclease activity  
    enables nucleotide binding  
    Process Evidence Code Pubs
    involved_in NAD-cap decapping  
    involved_in nuclear-transcribed mRNA catabolic process  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    Decapping nuclease dom-3
    NP_491496.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5003450..5004933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059095.8 → NP_491496.1  Decapping nuclease dom-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10660
      Conserved Domains (1) summary
      pfam08652
      Location:266 → 315
      RAI1; RAI1 like PD-(D/E)XK nuclease
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