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    ltd-1 Lim and transglutaminase domain protein ltd-1 [ Caenorhabditis elegans ]

    Gene ID: 174301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ltd-1
    Official Full Name
    Lim and transglutaminase domain protein ltd-1
    Primary source
    WormBase:WBGene00003089
    Locus tag
    CELE_K02C4.4
    See related
    AllianceGenome:WB:WBGene00003089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in muscle structure development. Located in cell-cell junction and cytoplasm. Is expressed in epithelial cell and isthmus. Human ortholog(s) of this gene implicated in myofibrillar myopathy 7. Orthologous to human KY (kyphoscoliosis peptidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ltd-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (8088427..8092754, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene FCH domain-containing protein Neighboring gene USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-2 Neighboring gene Sideroflexin-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and developmental expression of ltd-1 gene as a novel marker for epithelial cell development
      Title: Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle structure development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Lim and transglutaminase domain protein ltd-1
    NP_001309573.1
    • Confirmed by transcript evidence
    NP_495697.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8088427..8092754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063296.7 → NP_495697.2  Lim and transglutaminase domain protein ltd-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495697.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A131MD24, G5EF51
      Conserved Domains (2) summary
      cd09443
      Location:7 → 66
      LIM_Ltd-1; The LIM domain of LIM and transglutaminase domains protein (Ltd-1)
      COG5279
      Location:295 → 484
      CYK3; Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001322746.3 → NP_001309573.1  Lim and transglutaminase domain protein ltd-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD24
      Conserved Domains (1) summary
      COG5279
      Location:61 → 250
      CYK3; Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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