dnj-29 J domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dnj-29
Official Full Name: J domain-containing protein
Primary source: WormBase:WBGene00001047
Locus tag: CELE_Y63D3A.6
See related: AllianceGenome:WB:WBGene00001047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein transmembrane transporter activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane and post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dnj-29 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (14104515..14113108, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-220 (e-PCR)
- UniSTS:241714

Y63D3A.6a (e-PCR)
- UniSTS:320182

Y63D3A.7 (e-PCR)
- UniSTS:320766

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Sec62/Sec63 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: J domain-containing protein

NP_001369819.1

Confirmed by transcript evidence

NP_493464.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14104515..14113108 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383758.2 → NP_001369819.1 J domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1V9

Conserved Domains (2) summary

smart00611
Location:212 → 713

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

pfam00226
Location:107 → 165

DnaJ; DnaJ domain
NM_061063.5 → NP_493464.1 J domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493464.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1W0

Conserved Domains (2) summary

smart00611
Location:212 → 483

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

pfam00226
Location:107 → 165

DnaJ; DnaJ domain