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    chl-1 ATP-dependent DNA helicase chl-1 [ Caenorhabditis elegans ]

    Gene ID: 176457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chl-1
    Official Full Name
    ATP-dependent DNA helicase chl-1
    Primary source
    WormBase:WBGene00010839
    Locus tag
    CELE_M03C11.2
    See related
    AllianceGenome:WB:WBGene00010839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA helicase activity. Involved in positive regulation of cell population proliferation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chl-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10399174..10405240, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene PH domain-containing protein Neighboring gene Histone acetyltransferase type B catalytic subunit Neighboring gene ATP-dependent zinc metalloprotease YME1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans. Chung G, et al. DNA Repair (Amst), 2011 Nov 10. PMID 21968058
    2. TILLING is an effective reverse genetics technique for Caenorhabditis elegans. Gilchrist EJ, et al. BMC Genomics, 2006 Oct 18. PMID 17049087, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results demonstrate a role for CHL-1 (M03C11.2) in cell proliferation and maintaining normal chromosome numbers.
      Title: CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase chl-1
    NP_499295.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10399174..10405240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066894.8 → NP_499295.2  ATP-dependent DNA helicase chl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499295.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21489
      Conserved Domains (3) summary
      TIGR00604
      Location:121 → 820
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:632 → 803
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:2 → 387
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21489.2

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