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    parg-2 Poly(ADP-ribose) glycohydrolase 2 [ Caenorhabditis elegans ]

    Gene ID: 186765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    parg-2
    Official Full Name
    Poly(ADP-ribose) glycohydrolase 2
    Primary source
    WormBase:WBGene00004052
    Locus tag
    CELE_H23L24.5
    See related
    AllianceGenome:WB:WBGene00004052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Is expressed in head neurons and tail neurons. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See parg-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (8712408..8715132, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tubulin polyglutamylase ttll-11 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene PNPLA domain-containing protein Neighboring gene Phosphatidylinositol-glycan biosynthesis class X protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression. St-Laurent JF, et al. DNA Repair (Amst), 2007 Mar 1. PMID 17188026
    2. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
    3. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article
    4. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. Bae W, et al. FEBS J, 2020 Mar. PMID 31593615
    5. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(ADP-ribose) glycohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-sugar metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-sugar metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-sugar metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Poly(ADP-ribose) glycohydrolase 2
    NP_501496.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8712408..8715132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069095.5 → NP_501496.2  Poly(ADP-ribose) glycohydrolase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501496.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5L4
      Conserved Domains (1) summary
      pfam05028
      Location:116 → 435
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5L4.2

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