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    tag-335 Mannose-1-phosphate guanylyltransferase catalytic subunit beta [ Caenorhabditis elegans ]

    Gene ID: 183400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-335
    Official Full Name
    Mannose-1-phosphate guanylyltransferase catalytic subunit beta
    Primary source
    WormBase:WBGene00016583
    Locus tag
    CELE_C42C1.5
    See related
    AllianceGenome:WB:WBGene00016583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannose-1-phosphate guanylyltransferase (GTP) activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in cytoplasm. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B14. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-335 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (12276090..12278594, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL34 Neighboring gene Ovule protein Neighboring gene Vacuolar protein sorting-associated protein 8 central domain-containing protein;Vps8 domain-containing protein Neighboring gene Protein-lysine methyltransferase vkmt-1 Neighboring gene Aminopeptidase ltah-1.1 Neighboring gene PAP2_C domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-1-phosphate guanylyltransferase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-1-phosphate guanylyltransferase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mannose-1-phosphate guanylyltransferase catalytic subunit beta
    NP_502333.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12276090..12278594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069932.7 → NP_502333.2  Mannose-1-phosphate guanylyltransferase catalytic subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502333.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3QMC8
      Conserved Domains (3) summary
      cd06425
      Location:1 → 232
      M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
      COG1208
      Location:1 → 354
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:260 → 339
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3QMC8.1

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