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    mlt-4 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlt-4
    Official Full Name
    ANK_REP_REGION domain-containing protein
    Primary source
    WormBase:WBGene00013835
    Locus tag
    CELE_ZC15.7
    See related
    AllianceGenome:WB:WBGene00013835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cilium. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlt-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (20281387..20289417, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. Lažetić V, et al. Genetics, 2017 Jan. PMID 27799278, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to ciliary inversin compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein
    NP_507912.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20281387..20289417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075511.6 → NP_507912.2  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507912.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBJ4
      Conserved Domains (4) summary
      PHA03095
      Location:201 → 452
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:115 → 314
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:346 → 379
      ANK; ANK repeat [structural motif]
      cl39094
      Location:52 → 152
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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