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    mdt-31 Mediator of RNA polymerase II transcription subunit 31 [ Caenorhabditis elegans ]

    Gene ID: 185213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdt-31
    Official Full Name
    Mediator of RNA polymerase II transcription subunit 31
    Primary source
    WormBase:WBGene00007026
    Locus tag
    CELE_F32H2.2
    See related
    AllianceGenome:WB:WBGene00007026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED31 (mediator complex subunit 31). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mdt-31 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (8966114..8967004)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene snRNA-activating protein complex subunit 4 homolog Neighboring gene Spindle-defective protein 2 Neighboring gene Integrator complex subunit 1 R4 domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene SRCR domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
    2. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563
    3. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151
    4. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mediator of RNA polymerase II transcription subunit 31
    NP_001250947.1
    • Confirmed by transcript evidence
    NP_001250948.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8966114..8967004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264018.4 → NP_001250947.1  Mediator of RNA polymerase II transcription subunit 31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      I2HAC0, P91869
      Conserved Domains (1) summary
      pfam05669
      Location:23 → 116
      Med31; SOH1

    2. NM_001264019.3 → NP_001250948.1  Mediator of RNA polymerase II transcription subunit 31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAC1
      Conserved Domains (1) summary
      pfam05669
      Location:11 → 103
      Med31; SOH1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91869.2

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