strd-1 STE20-related kinase adapter protein strd-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: strd-1
Official Full Name: STE20-related kinase adapter protein strd-1
Primary source: WormBase:WBGene00013132
Locus tag: CELE_Y52D3.1
See related: AllianceGenome:WB:WBGene00013132
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including asymmetric neuroblast division; maintenance of dauer; and positive regulation of peptidyl-threonine phosphorylation. Located in several cellular components, including cell body; cell cortex; and neuron projection. Is expressed in excretory canal; nervous system; and pharynx. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha) and STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See strd-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (10947455..10951055)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

strd-1/STRAD mutants recapitulate many phenotypes typical of par-4/LKB1 loss of function, showing defects during early embryonic and dauer development.
Title: Differential requirements for STRAD in LKB1-dependent functions in C. elegans.
STRD-1 establishes neuronal polarity and organizes synaptic proteins in a complex with the SAD-1 kinase
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y52D3.1 (e-PCR)
- UniSTS:313335

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of dauer	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: STE20-related kinase adapter protein strd-1

NP_001022902.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10947455..10951055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027731.6 → NP_001022902.1 STE20-related kinase adapter protein strd-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022902.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECN5

Conserved Domains (2) summary

smart00220
Location:64 → 335

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:59 → 329

PKc_like; Protein Kinases, catalytic domain