abts-3 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: abts-3
Official Full Name: Bicarbonate transporter-like transmembrane domain-containing protein
Primary source: WormBase:WBGene00019018
Locus tag: CELE_F57F10.1
See related: AllianceGenome:WB:WBGene00019018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion homeostasis and transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in hypodermis and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See abts-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 20

Sequence:: Chromosome: II; NC_003280.10 (6132895..6157184)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57F10.1 (e-PCR)
- UniSTS:311914

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in borate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bicarbonate transporter-like transmembrane domain-containing protein

NP_001355398.1

Partially confirmed by transcript evidence

NP_001355414.1

Confirmed by transcript evidence

NP_001367590.1

Confirmed by transcript evidence

NP_001367591.1

Confirmed by transcript evidence

NP_495228.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6132895..6157184

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001368589.3 → NP_001355398.1 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E4W4

Conserved Domains (2) summary

COG1762
Location:133 → 294

PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]

pfam00955
Location:334 → 824

HCO3_cotransp; HCO3- transporter family
NM_001381448.2 → NP_001367590.1 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQ15

Conserved Domains (1) summary

pfam00955
Location:253 → 743

HCO3_cotransp; HCO3- transporter family
NM_001381447.1 → NP_001367591.1 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G4S481, Q3Y415

Conserved Domains (1) summary

pfam00955
Location:346 → 836

HCO3_cotransp; HCO3- transporter family
NM_001368590.4 → NP_001355414.1 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E616

Conserved Domains (2) summary

COG1762
Location:298 → 459

PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]

pfam00955
Location:499 → 989

HCO3_cotransp; HCO3- transporter family
NM_062827.6 → NP_495228.1 Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495228.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBE4

Conserved Domains (2) summary

COG1762
Location:214 → 375

PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]

pfam00955
Location:415 → 905

HCO3_cotransp; HCO3- transporter family