uev-3 UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: uev-3
Official Full Name: UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2
Primary source: WormBase:WBGene00006732
Locus tag: CELE_F26H9.7
See related: AllianceGenome:WB:WBGene00006732
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be located in several cellular components, including axon; cilium; and dendrite. Predicted to be active in nucleus. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See uev-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (9310319..9312642)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UEV-3 may provide additional specificity in the DLK-1 pathway by contributing to activation of PMK-3 or limiting the substrates accessible to PMK-3
Title: A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26H9.7 (e-PCR)
- UniSTS:317707

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2

NP_001361859.1

Confirmed by transcript evidence

NP_001362168.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9310319..9312642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001375060.3 → NP_001362168.1 UBC core domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P91853

UniProtKB/TrEMBL

A0A5K1ICF0

Conserved Domains (2) summary

PHA03247
Location:9 → 73

PHA03247; large tegument protein UL36; Provisional

cl00154
Location:147 → 281

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001375057.2 → NP_001361859.1 Ubiquitin-conjugating enzyme E2 variant 3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P91853

Conserved Domains (2) summary

PHA03247
Location:9 → 73

PHA03247; large tegument protein UL36; Provisional

cl00154
Location:185 → 319

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...