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    gcy-5 Receptor-type guanylate cyclase gcy-5 [ Caenorhabditis elegans ]

    Gene ID: 191643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-5
    Official Full Name
    Receptor-type guanylate cyclase gcy-5
    Primary source
    WormBase:WBGene00001532
    Locus tag
    CELE_ZK970.6
    See related
    AllianceGenome:WB:WBGene00001532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in response to salt. Located in cilium. Is expressed in nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (10310400..10316219, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mss4 protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene Lipoprotein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro. Chen N, et al. PLoS One, 2014. PMID 25412474, Free PMC Article
    2. Vector-free DNA constructs improve transgene expression in C. elegans. Etchberger JF, et al. Nat Methods, 2008 Jan. PMID 18165801
    3. The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans. Pierce-Shimomura JT, et al. Nature, 2001 Apr 5. PMID 11287956
    4. Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis. Horspool AM, et al. Redox Biol, 2018 Jul. PMID 29857312, Free PMC Article
    5. Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during Fusarium infection of Caenorhabditis elegans. Nag P, et al. Cell Death Discov, 2017. PMID 29152379, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-5
    NP_496219.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10310400..10316219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063818.1 → NP_496219.1  Receptor-type guanylate cyclase gcy-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23682
      Conserved Domains (6) summary
      cd06352
      Location:30 → 440
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:852 → 1042
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd13992
      Location:546 → 816
      PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
      pfam00211
      Location:879 → 1067
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:49 → 426
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:830 → 873
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23682.1

    Gene LinkOut

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