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    magu-4 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177860, updated on 9-Dec-2024

    Summary

    Official Symbol
    magu-4
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00009678
    Locus tag
    CELE_F44D12.1
    See related
    AllianceGenome:WB:WBGene00009678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in negative regulation of hippo signaling. Is expressed in hypodermis; neurons; pharynx; spermatheca; and vulval cell. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See magu-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (10009753..10014207)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF281 domain-containing protein Neighboring gene ncRNA Neighboring gene Equilibrative Nucleoside Transporter (ENT) Family Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    PDZ domain-containing protein
    NP_001368189.1
    • Confirmed by transcript evidence
    NP_501805.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10009753..10014207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069404.6NP_501805.2  PDZ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20398
      Conserved Domains (4) summary
      cd11860
      Location:807869
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      cd00992
      Location:230315
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17190
      Location:9551071
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl25732
      Location:28217
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001380427.2NP_001368189.1  PDZ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F5A3
      Conserved Domains (4) summary
      cd11860
      Location:805867
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      cd00992
      Location:230315
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam13868
      Location:29215
      TPH; Trichohyalin-plectin-homology domain
      cl17190
      Location:9531069
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...