pars-1 proline--tRNA ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pars-1
Official Full Name: proline--tRNA ligase
Primary source: WormBase:WBGene00004189
Locus tag: CELE_T20H4.3
See related: AllianceGenome:WB:WBGene00004189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pars-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (7239027..7241277)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20H4.3 (e-PCR)
- UniSTS:310918

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proline-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in prolyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in prolyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proline--tRNA ligase

NP_001022778.1

Confirmed by transcript evidence

NP_001370820.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7239027..7241277

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382911.2 → NP_001370820.1 proline--tRNA ligase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q22620

Conserved Domains (2) summary

PRK08661
Location:93 → 581

PRK08661; prolyl-tRNA synthetase; Provisional

cl00349
Location:14 → 57

S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...
NM_001027607.5 → NP_001022778.1 proline--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022778.1

Status: REVIEWED

UniProtKB/TrEMBL

Q65ZK5

Conserved Domains (4) summary

PRK08661
Location:93 → 449

PRK08661; prolyl-tRNA synthetase; Provisional

cd00778
Location:98 → 361

ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cl00266
Location:367 → 451

HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

cl00349
Location:14 → 57

S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...