unc-10 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-10
Official Full Name: Rab-3-interacting molecule unc-10
Primary source: WormBase:WBGene00006750
Locus tag: CELE_T10A3.1
See related: AllianceGenome:WB:WBGene00006750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Is expressed in nervous system and uv1. Orthologous to several human genes including RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-10 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 28

Sequence:: Chromosome: X; NC_003284.9 (7272317..7280322, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans.
Title: RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans.
Here the authors show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: forming C2A/C2A homodimers, or forming a heterodimer with the zinc finger domain of UNC-10/RIM (C2A/RIM).
Title: Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans.
we propose that the dense projection ensures proper coupling of primed vesicles with calcium signaling by retaining them at the active zone via unc-10 and SYD-2 dependent mechanisms
Title: The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.
SYD-2, SYD-1 and UNC-10 were found essential for presynaptic site active zone assembly at synapses.
Title: The Yin and Yang of synaptic active zone assembly.
Vesicles targeted to the presynaptic density by RAB-3/UNC-10 interactions are ideally positioned for efficient calcium-dependent release.
Title: Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K03A1.3 (e-PCR)
- UniSTS:311385

T10A3.1 (e-PCR)
- UniSTS:310769

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rab-3-interacting molecule unc-10

NP_001024901.1

Confirmed by transcript evidence

NP_001362125.1

Confirmed by transcript evidence

NP_001362126.1

Confirmed by transcript evidence

NP_001362127.1

Confirmed by transcript evidence

NP_001362128.1

Confirmed by transcript evidence

NP_741831.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7272317..7280322 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001375067.2 → NP_001362125.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LYK9

Conserved Domains (4) summary

cd04028
Location:1368 → 1514

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:827 → 950

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:630 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:11 → 130

PHD_SF; PHD finger superfamily
NM_001029730.6 → NP_001024901.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024901.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22366

Conserved Domains (4) summary

cd04031
Location:840 → 963

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

COG0265
Location:674 → 755

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:643 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:11 → 130

PHD_SF; PHD finger superfamily
NM_171720.7 → NP_741831.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741831.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22366, Q22367, Q8MPX5, Q95WX9

Conserved Domains (5) summary

cd04028
Location:1402 → 1548

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:840 → 963

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

COG0265
Location:674 → 755

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:643 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:11 → 130

PHD_SF; PHD finger superfamily
NM_001375066.2 → NP_001362127.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LXW2

Conserved Domains (4) summary

cd04028
Location:1263 → 1409

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:827 → 950

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:630 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:11 → 130

PHD_SF; PHD finger superfamily
NM_001375064.2 → NP_001362128.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4M2M0

Conserved Domains (4) summary

cd04028
Location:1261 → 1407

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:825 → 948

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:628 → 716

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:11 → 130

PHD_SF; PHD finger superfamily
NM_001375065.2 → NP_001362126.1 Rab-3-interacting molecule unc-10 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LWH4