U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    srf-3 UDP-galactose/UDP-N-acetylglucosamine transporter srf-3 [ Caenorhabditis elegans ]

    Gene ID: 187393, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    srf-3
    Official Full Name
    UDP-galactose/UDP-N-acetylglucosamine transporter srf-3
    Primary source
    WormBase:WBGene00005153
    Locus tag
    CELE_M02B1.1
    See related
    AllianceGenome:WB:WBGene00005153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables UDP-N-acetylglucosamine transmembrane transporter activity and UDP-galactose transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport and UDP-galactose transmembrane transport. Located in Golgi membrane and perinuclear region of cytoplasm. Is expressed in pharyngeal gland cell; seam cell; spermatheca; and vas deferens. Used to study bacterial infectious disease. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See srf-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (12849510..12854408)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene TLC domain-containing protein Neighboring gene transcellular chaperone signaling (x)cross tissue Neighboring gene UDP-galactose transporter Neighboring gene Receptor-type guanylate cyclase gcy-18

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Altered expression of an L1-specific, O-linked cuticle surface glycoprotein in mutants of the nematode Caenorhabditis elegans. Hemmer RM, et al. J Cell Biol, 1991 Dec. PMID 1955471, Free PMC Article
    2. Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence. Höflich J, et al. J Biol Chem, 2004 Jul 16. PMID 15123614
    3. srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates. Cipollo JF, et al. J Biol Chem, 2004 Dec 17. PMID 15452127
    4. Soil nematodes mediate positive interactions between legume plants and rhizobium bacteria. Horiuchi J, et al. Planta, 2005 Nov. PMID 16025342
    5. A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans. Hodgkin J, et al. Curr Biol, 2000 Dec 14-28. PMID 11137017

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine nucleotide-sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    UDP-galactose/UDP-N-acetylglucosamine transporter srf-3
    NP_001255676.1
    • Confirmed by transcript evidence
    NP_001255677.1
    • Confirmed by transcript evidence
    NP_001255678.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12849510..12854408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268747.3 → NP_001255676.1  UDP-galactose/UDP-N-acetylglucosamine transporter srf-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255676.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02348, Q93890
      Conserved Domains (1) summary
      pfam04142
      Location:40 → 343
      Nuc_sug_transp; Nucleotide-sugar transporter

    2. NM_001268748.3 → NP_001255677.1  UDP-galactose/UDP-N-acetylglucosamine transporter srf-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFD3
      Conserved Domains (2) summary
      pfam04142
      Location:1 → 303
      Nuc_sug_transp; Nucleotide-sugar transporter
      cl23754
      Location:79 → 302
      EamA; EamA-like transporter family

    3. NM_001268749.3 → NP_001255678.1  UDP-galactose/UDP-N-acetylglucosamine transporter srf-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB7
      Conserved Domains (1) summary
      cl23754
      Location:2 → 218
      EamA; EamA-like transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93890.5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous