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    aps-1 AP complex subunit sigma [ Caenorhabditis elegans ]

    Gene ID: 178989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aps-1
    Official Full Name
    AP complex subunit sigma
    Primary source
    WormBase:WBGene00000159
    Locus tag
    CELE_F29G9.3
    See related
    AllianceGenome:WB:WBGene00000159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in apical protein localization. Predicted to be located in Golgi apparatus; clathrin-coated pit; and cytoplasmic vesicle. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aps-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (6017970..6018886)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transcription factor fos-1 Neighboring gene putative 26S proteasome regulatory subunit 4 Neighboring gene ncRNA Neighboring gene PAC-1 interacting and coiled-coil domain-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. Tsang WY, et al. J Biol Chem, 2001 Aug 24. PMID 11410594
    2. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Kamikura DM, et al. Genes Dev, 2003 Nov 15. PMID 14630941, Free PMC Article
    3. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Gillard G, et al. Development, 2015 May 1. PMID 25858456
    4. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article
    5. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Li P, et al. Neuron, 2016 May 4. PMID 27151641, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP complex subunit sigma
    NP_001379652.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6017970..6018886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392525.1 → NP_001379652.1  AP complex subunit sigma [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16369
      Conserved Domains (1) summary
      cd14831
      Location:3 → 145
      AP1_sigma; AP-1 complex subunit sigma
    Nucleotide Protein
    Heading Accession and Version

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