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    flr-1 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 181468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flr-1
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00001465
    Locus tag
    CELE_F02D10.5
    See related
    AllianceGenome:WB:WBGene00001465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Involved in defecation and ultradian rhythm. Located in nuclear membrane and plasma membrane. Is expressed in intestine. Orthologous to human ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    17
    Sequence:
    Chromosome: X; NC_003284.9 (13452667..13456542, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Protein TEX261 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ssl1 domain-containing protein Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase. Kobayashi Y, et al. Genes Cells, 2011 May. PMID 21518154
    2. Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock. Kaulich E, et al. Elife, 2022 Jun 6. PMID 35666106, Free PMC Article
    3. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi M, et al. Proc Natl Acad Sci U S A, 1998 Sep 29. PMID 9751741, Free PMC Article
    4. FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans. Take-uchi M, et al. Mol Biol Cell, 2005 Mar. PMID 15647385, Free PMC Article
    5. Genes that control a temperature-compensated ultradian clock in Caenorhabditis elegans. Iwasaki K, et al. Proc Natl Acad Sci U S A, 1995 Oct 24. PMID 7479775, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that FLR-1 and FLR-4 are often colocalized in the plasma membrane.
      Title: Ultradian rhythm in the intestine of Caenorhabditis elegans is controlled by the C-terminal region of the FLR-1 ion channel and the hydrophobic domain of the FLR-4 protein kinase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ultradian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_510243.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13452667..13456542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077842.5 → NP_510243.1  Uncharacterized protein CELE_F02D10.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGI5
      Conserved Domains (1) summary
      pfam00858
      Location:22 → 450
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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