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    pik-1 Pelle-like serine/threonine-protein kinase pik-1 [ Caenorhabditis elegans ]

    Gene ID: 178306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pik-1
    Official Full Name
    Pelle-like serine/threonine-protein kinase pik-1
    Primary source
    WormBase:WBGene00004029
    Locus tag
    CELE_K09B11.1
    See related
    AllianceGenome:WB:WBGene00004029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in cell surface receptor signaling pathway and intracellular signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in arthritis (multiple); asthma; diffuse scleroderma; primary immunodeficiency disease (multiple); and squamous cell carcinoma. Orthologous to several human genes including IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pik-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (13416041..13422391)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene Neuropeptide-Like Protein Neighboring gene BTB domain-containing protein Neighboring gene Transcription factor aptf-2 Neighboring gene ncRNA Neighboring gene Polynucleotide 5'-hydroxyl-kinase nol-9 Neighboring gene Ovule protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IL-17: good fear no tears. Rua R, et al. Nat Immunol, 2020 Nov. PMID 32958929
    2. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Chen C, et al. Nature, 2017 Feb 2. PMID 28099418, Free PMC Article
    3. Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Aballay A, et al. Curr Biol, 2003 Jan 8. PMID 12526744
    4. A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Pujol N, et al. Curr Biol, 2001 Jun 5. PMID 11516642
    5. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Toll signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pelle-like serine/threonine-protein kinase pik-1
    NP_001255742.1
    • Confirmed by transcript evidence
    NP_001255743.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13416041..13422391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268813.5 → NP_001255742.1  Pelle-like serine/threonine-protein kinase pik-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F5GUH7, G5ECP4
      Conserved Domains (2) summary
      cd08307
      Location:8 → 107
      Death_Pelle; Death domain of the protein kinase Pelle
      cd14066
      Location:191 → 478
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

    2. NM_001268814.3 → NP_001255743.1  Pelle-like serine/threonine-protein kinase pik-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUH7
      Conserved Domains (3) summary
      smart00220
      Location:149 → 434
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14066
      Location:151 → 438
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      cl14633
      Location:1 → 67
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. NR_056884.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECP4.1

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