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    lgc-38 Gamma-aminobutyric acid receptor subunit beta [ Caenorhabditis elegans ]

    Gene ID: 3565717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-38
    Official Full Name
    Gamma-aminobutyric acid receptor subunit beta
    Primary source
    WormBase:WBGene00017389
    Locus tag
    CELE_F11H8.2
    See related
    AllianceGenome:WB:WBGene00017389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in head; intestine; neurons; pharynx; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-38 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (7009136..7019584)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Cuticle collagen 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NEDD8-activating enzyme E1 catalytic subunit Neighboring gene WAPL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging. Cheng H, et al. Neuron, 2024 May 1. PMID 38447577
    2. A sleep-active neuron can promote survival while sleep behavior is disturbed. Busack I, et al. PLoS Genet, 2023 Mar. PMID 36917595, Free PMC Article
    3. GABA. Jorgensen EM. WormBook, 2005 Aug 31. PMID 18050397, Free PMC Article
    4. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
    5. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Singh K, et al. Sleep, 2014 Sep 1. PMID 25142568, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-aminobutyric acid receptor subunit beta
    NP_001355511.1
    • Confirmed by transcript evidence
    NP_498532.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7009136..7019584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066131.8 → NP_498532.4  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6MY79
      Conserved Domains (2) summary
      TIGR00860
      Location:42 → 457
      LIC; Cation transporter family protein
      cd19008
      Location:76 → 257
      LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

    2. NM_001368434.4 → NP_001355511.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NNS2
      Conserved Domains (2) summary
      TIGR00860
      Location:42 → 476
      LIC; Cation transporter family protein
      cd19008
      Location:76 → 257
      LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)
    Nucleotide Protein
    Heading Accession and Version

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