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    sph-1 MARVEL domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sph-1
    Official Full Name
    MARVEL domain-containing protein
    Primary source
    WormBase:WBGene00004979
    Locus tag
    CELE_F42G8.11
    See related
    AllianceGenome:WB:WBGene00004979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in cytoplasmic vesicle. Is expressed in anal sphincter muscle and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to several human genes including SYPL1 (synaptophysin like 1) and SYNPR (synaptoporin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sph-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (8132175..8133558, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rhodanese domain-containing protein Neighboring gene ncRNA Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Neighboring gene Molybdopterin-synthase sulfurtransferase Neighboring gene ncRNA Neighboring gene Cytochrome b-c1 complex subunit Rieske, mitochondrial Neighboring gene ncRNA Neighboring gene Interactor with SLO-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans. Abraham C, et al. Proc Natl Acad Sci U S A, 2006 May 23. PMID 16698939, Free PMC Article
    2. Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2. Hüsken K, et al. Differentiation, 2008 Oct. PMID 18452552
    3. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Tanizawa Y, et al. Genes Dev, 2006 Dec 1. PMID 17158747, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MARVEL domain-containing protein
    NP_501360.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8132175..8133558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068959.8 → NP_501360.2  MARVEL domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501360.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44511
      Conserved Domains (1) summary
      pfam01284
      Location:85 → 210
      MARVEL; Membrane-associating domain
    Nucleotide Protein
    Heading Accession and Version

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