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    klu-1 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klu-1
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00013970
    Locus tag
    CELE_ZK337.2
    See related
    AllianceGenome:WB:WBGene00013970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in anal depressor muscle; body wall musculature; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klu-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (14975419..14980596)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transcription factor ces-2 Neighboring gene Secreted phosphoprotein 24 Neighboring gene DBD_Tnp_Mut domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    2. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_493611.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14975419..14980596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061210.7 → NP_493611.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493611.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46016
      Conserved Domains (4) summary
      COG5048
      Location:395 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:371 → 391
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:369 → 391
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:411 → 436
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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