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    • Showing Current items.

    flp-6 QQDSEVEREMM [ Caenorhabditis elegans ]

    Gene ID: 179327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-6
    Official Full Name
    QQDSEVEREMM
    Primary source
    WormBase:WBGene00001449
    Locus tag
    CELE_F07D3.2
    See related
    AllianceGenome:WB:WBGene00001449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable receptor ligand activity. Involved in several processes, including determination of adult lifespan; germ-line stem cell population maintenance; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including anal region; ciliated neurons; head; head mesodermal cell; and interneuron. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (9471975..9473792)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans. Marks NJ, et al. Biochem Biophys Res Commun, 1998 Jul 20. PMID 9675153
    2. Heat FLiPs a Hormonal Switch for Longevity. Artan M, et al. Dev Cell, 2016 Oct 24. PMID 27780036
    3. Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans. Thapliyal S, et al. Nat Commun, 2023 May 26. PMID 37236963, Free PMC Article
    4. Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans. Levi-Ferber M, et al. Elife, 2021 Sep 3. PMID 34477553, Free PMC Article
    5. A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling. Chen YC, et al. Dev Cell, 2016 Oct 24. PMID 27720609

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both CRH-1 and FLP-6 are necessary and sufficient for longevity at warm temperatures.
      Title: A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables receptor ligand activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    QQDSEVEREMM
    NP_505444.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9471975..9473792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073043.6 → NP_505444.1  QQDSEVEREMM [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81283, Q19165, Q21257, Q9TZZ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19165.3

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