hbl-1 C2H2-type domain-containing protein;Hunchback-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hbl-1
Official Full Name: C2H2-type domain-containing protein;Hunchback-like protein
Primary source: WormBase:WBGene00001824
Locus tag: CELE_F13D11.2
See related: AllianceGenome:WB:WBGene00001824
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and nematode larval development. Located in nucleus. Is expressed in several structures, including body wall musculature; germ line; hypodermis; neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hbl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (5822142..5827755)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

robust progression from L2 to L3 cell fates depends on the combination of two distinct modes of HBL-1 downregulation: decreased synthesis of HBL-1 via let-7-family microRNA activity, and decreased nuclear accumulation of HBL-1 via action of the lin-28-lin-46 pathway
Title: Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans.
This study demonistrated that convergent regulation of hbl-1 expression defines a genetic mechanism that patterns activity-dependent synaptic remodeling across cell types and across developmental time.
Title: HBL-1 patterns synaptic remodeling in C. elegans.
hbl-1 can also modulate the dauer formation decision in a complex manner
Title: The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans.
Given that SYM-1 is a protein secreted from hypodermal cells to the surrounding cuticle, we propose that the adult-specific cuticular structures may be under the temporal control of HBL-1 through regulation of sym-1 transcription.
Title: C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor.
propose that hunchback, Ikaros, and the HIL genes arose from a common ancestor that was present prior to the divergence of protostomes and deuterostomes
Title: hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.
One of let-7's targets, HBL-1, inhibits the transcription of let-7 in specific tissues until the L3 stage via a negative feedback loop.
Title: Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1.
Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning.
Title: The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.
hbl-1/lin-57 is regulated by let-7
Title: The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.
Temporal regulator hbl-1, the Caenorhabditis elegans ortholog of hunchback, interacts with puf-9; this regulation is dependent on a region of the hbl-1 3'UTR that contains putative Puf family binding sites.
Title: The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F13D11.2 (e-PCR)
- UniSTS:309712

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of development, heterochronic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C2H2-type domain-containing protein;Hunchback-like protein

NP_001041243.1

Confirmed by transcript evidence

NP_001041244.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5822142..5827755

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047778.5 → NP_001041243.1 Hunchback-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041243.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19389, Q9XYD3

Conserved Domains (2) summary

sd00017
Location:569 → 589

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:609 → 634

zf-H2C2_2; Zinc-finger double domain
NM_001047779.5 → NP_001041244.1 C2H2-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041244.1

Status: REVIEWED

UniProtKB/TrEMBL

Q27GU0

Conserved Domains (2) summary

sd00017
Location:547 → 567

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:587 → 612

zf-H2C2_2; Zinc-finger double domain