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    toe-4 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    toe-4
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00012194
    Locus tag
    CELE_W02A11.3
    See related
    AllianceGenome:WB:WBGene00012194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in several structures, including head; hypodermis; intestine; rectal gland cell; and vulval muscle. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See toe-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (12738087..12741146)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative prefoldin subunit 3 Neighboring gene tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A Neighboring gene tRNA Neighboring gene Vacuolar protein-sorting-associated protein 25 Neighboring gene SUMO-activating enzyme subunit uba-2 Neighboring gene BTB and MATH domain-containing protein 34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. Ohno G, et al. PLoS Genet, 2012. PMID 23071450, Free PMC Article
    2. Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis. Benavidez JM, et al. G3 (Bethesda), 2022 Apr 4. PMID 35134193, Free PMC Article
    3. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
    4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
    5. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_493231.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12738087..12741146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060830.8 → NP_493231.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUM8
      Conserved Domains (1) summary
      cd16474
      Location:431 → 475
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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