scpl-1 CTD small phosphatase-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: scpl-1
Official Full Name: CTD small phosphatase-like protein 1
Primary source: WormBase:WBGene00007054
Locus tag: CELE_B0379.4
See related: AllianceGenome:WB:WBGene00007054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Orthologous to several human genes including CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See scpl-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (10086265..10102012, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCPL-1 interacts with LIM-9 (FHL), a protein that we first discovered as an interactor of UNC-97 (PINCH) and UNC-96, components of an M-line costamere in nematode muscle.
Title: A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
Yeast two-hybrid screening using a portion of UNC-89 including PK2, yielded SCPL-1 (small CTD phosphatase-like-1), which contains a C terminal domain (CTD) phosphatase type domain.
Title: A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0379.6 (e-PCR)
- UniSTS:315321

B0379.4 (e-PCR)
- UniSTS:318964

B0379.5 (e-PCR)
- UniSTS:318965

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables LIM domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CTD small phosphatase-like protein 1

NP_001122411.1

Confirmed by transcript evidence

NP_001370133.1

Confirmed by transcript evidence

NP_740912.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10086265..10102012 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128939.3 → NP_001122411.1 CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T3G2

Conserved Domains (2) summary

COG5190
Location:66 → 224

FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]

TIGR02251
Location:70 → 224

HIF-SF_euk; Dullard-like phosphatase domain
NM_001383711.2 → NP_001370133.1 CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

TIGR02251
Location:165 → 319

HIF-SF_euk; Dullard-like phosphatase domain
NM_170918.7 → NP_740912.2 CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740912.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A5Z2W8, Q8T3G2, Q8T3G3

Conserved Domains (1) summary

TIGR02251
Location:311 → 465

HIF-SF_euk; Dullard-like phosphatase domain