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    fem-3 Sex-determination protein fem-3 [ Caenorhabditis elegans ]

    Gene ID: 177734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fem-3
    Official Full Name
    Sex-determination protein fem-3
    Primary source
    WormBase:WBGene00001413
    Locus tag
    CELE_C01F6.4
    See related
    AllianceGenome:WB:WBGene00001413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein phosphatase binding activity. Involved in several processes, including male somatic sex determination; masculinization of hermaphroditic germ-line; and positive regulation of macromolecule metabolic process. Located in cytoplasm. Part of protein-containing complex. Is expressed in germ line; spermatid; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fem-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (9104966..9107607)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Ovule protein Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Wang Y, et al. Proc Natl Acad Sci U S A, 2009 Dec 1. PMID 19901328, Free PMC Article
    2. Repression by the 3' UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. Gallegos M, et al. EMBO J, 1998 Nov 2. PMID 9799241, Free PMC Article
    3. The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA. Zanetti S, et al. RNA, 2012 Jul. PMID 22635404, Free PMC Article
    4. Sex determination in the Caenorhabditis elegans germline. Zanetti S, et al. Adv Exp Med Biol, 2013. PMID 22872474
    5. A comparison of mutations induced by accelerated iron particles versus those induced by low earth orbit space radiation in the FEM-3 gene of Caenorhabditis elegans. Hartman PS, et al. Mutat Res, 2001 Mar 1. PMID 11239962

    See all (233) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the N-terminal domain (NTD) works in mediating the sex-determining role of FEM-1/2/3 complex.
      Title: Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.
    2. It was shown that FEM-3 is exclusively present in germ cells that are committed to spermatogenesis. In fem- 3(gf)/+ heterozygotes, mutant fem-3 gain-of-function transcripts are more abundant than their wild-type counterpart.
      Title: The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA.
    3. Pumilio-fem-3 mRNA binding factor (PUF) RNA-binding proteins achieve that specificity through variations on a conserved scaffold.
      Title: Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket.
    4. our data indicate that LARP-1 and NOS-3 promote oogenesis by regulating fem-3 expression through distinct mechanisms.
      Title: LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.
    5. Results suggest that SEL-10-mediated proteolysis of FEM-1 and FEM-3 is required for normal hermaphrodite development.
      Title: The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male somatic sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in masculinization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sex-determination protein fem-3
    NP_001255365.1
    • Confirmed by transcript evidence
    NP_001255366.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9104966..9107607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268436.4 → NP_001255365.1  Sex-determination protein fem-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34691

    2. NM_001268437.3 → NP_001255366.1  Sex-determination protein fem-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L280

    RNA

    1. NR_056354.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34691.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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