gpa-4 Guanine nucleotide-binding protein alpha-4 subunit [Caenorhabditis elegans] - Gene

Summary

Official Symbol: gpa-4
Official Full Name: Guanine nucleotide-binding protein alpha-4 subunit
Primary source: WormBase:WBGene00001666
Locus tag: CELE_T07A9.7
See related: AllianceGenome:WB:WBGene00001666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is expressed in several structures, including P lineage cell; neurons; seam cell; somatic gonad; and vulval precursor cell. Human ortholog(s) of this gene implicated in achromatopsia 4; color blindness; congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to several human genes including GNAI1 (G protein subunit alpha i1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

NP_499921.2

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The following sections contain reference sequences that belong to a specific genome build. Explain